This site requires Cookies enabled in your browser for login.
. . .
Alias List Editor
Publication 2020: Target Self-enhanced Selectivity in Metal-specific DNAzymes
Section 1: Publication
Huang, P., de Rochambeau, D., Sleiman, H., Liu, J.
Target Self-enhanced Selectivity in Metal-specific DNAzymes
Angewandte Chemie International Edition, 132, 3601-3605
Huang, P., de Rochambeau, D., Sleiman, H., Liu, J. (2020) Target Self-enhanced Selectivity in Metal-specific DNAzymes, Angewandte Chemie International Edition, 132, 3601-3605.
Sensors and Sensing Systems for Water Quality Monitoring
Section 2: Abstract
Highly selective recognition of metal ions by rational ligand design is challenging, and simple metal binding by biological ligands is often obscured by nonspecific interactions. In this work, binding-triggered catalysis is used and metal selectivity is greatly increased by increasing the number of metal ions involved, as exemplified in a series of in vitro selected RNA-cleaving DNAzymes. The cleavage junction is modified with a glycyl–histidine-functionalized tertiary amine moiety to provide multiple potential metal coordination sites. DNAzymes that bind 1, 2, and 3 Zn2+ ions, increased their selectivity for Zn2+ over Co2+ ions from approximately 20-, 1000-, to 5000-fold, respectively. This study offers important insights into metal recognition by combining rational ligand design and combinatorial selection, and it provides a set of new DNAzymes with excellent selectivity for Zn2+ ions.
Section 3: Download
Section 4: Computed Information
T-2022-11-03-31rDvIfNnjUaGKdpkd4v33TQ Publication 1.0